Fosfomycin Tromethamine

A to Z Drug Facts

Fosfomycin Tromethamine

	Action
	Indications
	Contraindications
	Route/Dosage
	Interactions
	Lab Test Interferences
	Adverse Reactions
	Precautions
Patient Care Considerations
	Administration/Storage
	Assessment/Interventions
	Patient/Family Education

(foss-foe-MY-sin troe-METH-ah-meen)

Monurol

Class: Antibiotic

Action Interferes with bacterial cell wall biosynthesis.

Indications Treatment of uncomplicated UTI (acute cystitis) in women due to susceptible strains of specific microorganisms.

Contraindications Standard considerations.

Route/Dosage

ADULT WOMEN: PO One 3 g sachet dissolved in 3 to 4 oz of cool water.

Interactions

Metoclopramide: May decrease serum concentrations and urinary excretion of fosfomycin.

Lab Test Interferences None well documented.

Adverse Reactions

CNS: Headache; dizziness. DERM: Rash. EENT: Rhinitis; pharyngitis. GI: Diarrhea; nausea; dyspepsia; abdominal pain. GU: Vaginitis; dysmenorrhea. OTHER: Asthenia; back pain; pain.

Precautions

Pregnancy: Category B. Lactation: Undetermined. Children: Safety and efficacy not established. Elderly patients: No dosage adjustment necessary. Single dose: Do not use more than one single dose to treat a single episode of infection.

PATIENT CARE CONSIDERATIONS

Administration/Storage

Never take in dry form; always mix with water.
Pour the entire contents of the single-dose sachet into 3 to 4 oz of water and stir to dissolve.
Do not use hot water.
Administer immediately after mixing.
May be taken with or without food.
Store dry powder at room temperature (59° to 86° F).

Assessment/Interventions

Obtain patient history, including drug history and any known allergies.
Obtain urine for C&S prior to starting therapy.
Obtain results of CBC and other lab tests ordered by physician.
Obtain vital signs. Monitor weight and I&O.
Evaluate for signs of infection (eg, fever, chills, burning, frequency).
Monitor patient for side effects of drug. Report any to the physician.

Patient/Family Education

Instruct patient in proper preparation of medication.
Inform patient that this is a single-dose treatment and repeated doses do not improve the clinical success.
Advise patient that symptoms should improve in 2 to 3 days after taking drug. If symptoms do not improve, patient should contact physician.
Increase fluid intake to 2,000 to 3,000 ml/day.
Instruct the patient on proper personal hygiene to help prevent recurrence of infections.